- Product Details
Keywords
- HCY assay reagents
- biochemical raw material
- homocysteine test
Quick Details
- ProName: Cystathionine β-synthase
- Appearance: yellow amorphous freeze-dried powder
- Application: Cystathionine β-lyase is an enzyme tha...
- Port: air freight
- ProductionCapacity: Metric Ton/Day
- Purity: ≥95%
- Storage: -20°C
- Transportation: Cold Chain Shipping with Dry Ice
- LimitNum: 1 Gram
Superiority
Comes in a freeze-dried powdered form;
Features a modified molecular structure with higher stability and water solubility;
Simplify the process of reagent preparation by the accurate activity of CBS, reduced the difference batch to batch.
Details
Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. It catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine:
L-serine + L-homocysteine {\displaystyle \rightleftharpoons } L-cystathionine + H2O
CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds.
CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria.